Are pre-miR-146a and PTTG1 associated with papillary thyroid cancer?
نویسندگان
چکیده
منابع مشابه
Are pre-miR-146a and PTTG1 associated with papillary thyroid cancer?
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, with a steadily increasing incidence in the last few decades worldwide. The predisposition to developing this carcinoma by the heterozygous state of rs2910164 within the precursor of the miR-146a has been reported, but recently not confirmed. Interestingly, on the same chromosome, almost 50 kb separate the pre-miR-146a f...
متن کاملAssociation of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer
The incidence rate of papillary thyroid cancer (PTC) has increased over the past decades, but the pathogenesis remains unclear. rs2910164, located in pre-miR-146a, has been studied in PTCs with different ethnicity, but the results were inconsistent. Here we evaluate the association between rs2910164 polymorphism and PTC and investigate the effect of this polymorphism on patients' clinicopatholo...
متن کاملmiR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma
The present study investigated the relationship between the expression of miR-146a and miR‑146b with the occurrence and prognosis of papillary thyroid carcinoma. Experiments in vitro were also used to explore the effect of the knocked down expression of the miRNAs on growth and migration of papillary thyroid carcinoma cells. A total of 73 patients with papillary thyroid carcinoma admitted to Yi...
متن کاملPTTG1 regulated by miR-146a-3p promotes bladder cancer migration, invasion, metastasis and growth
Pituitary tumor-transforming gene 1 (PTTG1) is identified as an oncogene, and overexpresses in many tumors. However, the role of PTTG1 in bladder cancer (BC) hasn't yet been characterized well. In this study, we showed the expression of PTTG1 mRNA and protein were both significantly increased in BC tissues and cells. The PTTG1 protein levels were positive correlated with increased tumor size, t...
متن کاملPolymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer.
Prior work has shown that heterozygosity G/C of single nucleotide polymorphism (SNP rs2910164) within the precursor of microRNA-146a predisposes to PTC (odds ratio = 1.62, P = 0.000007) although the mechanism was unclear. Here, we show that GC heterozygotes differ from both GG and CC homozygotes by producing 3 mature microRNAs: 1 from the leading strand (miR-146a), and 2 from the passenger stra...
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ژورنال
عنوان ژورنال: Endocrine Connections
سال: 2013
ISSN: 2049-3614
DOI: 10.1530/ec-13-0066